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Journal of Nutrition Vol. 112 No. 7 July 1982, pp. 1379-1386
Copyright © 1982 by American Society for Nutrition
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Starvation-Induced Ketone Body Production in the Conscious Unrestrained Miniature Pig1,2,

Manfred James Müller, Ulrich Paschen and Hans Joachim Seitz

Institut für Physiologische Chemie, Universitäts-Krankenhaus Eppendorf, Universität Hamburg, Martinistr. 52, 2000 Hamburg 20, West Germany

The effect of short-term starvation (up to 5 days) on hepatic ketone body production was investigated in the conscious unrestrained miniature pig in vivo. Starvation induced an increase in arterial free fatty acid concentration (0.2– 0.7mM) with a concomitant elevation in hepatic free fatty acid extraction [-1.4–5.7 µmol/kg · minute), r = 0.53, P < 0.005]. Ketone body production (sum of acetoacetate + ß-hydroxybutyrate) increased from 1.5 to 5.8 µmol/(kg · minute) in parallel (r = 0.71, P < 0.0005). During starvation arterial insulin levels decreased, glucagon increased, cortisol remained unchanged and a "low T3 state" was observed. These data differ in some aspects from those reported for humans and dogs. Thus a species-specific variation in the fuel economy of the pig's body is proposed.

KEY WORDS: • starvation • miniature pig • hepatic ketogenesis • hepatic free fatty acid extraction

1 Supported by Deutsche Forschungsgemeinschaft, Sonderforschungsbereich-34-Endokrinologie.

2 In conducting the research described in this report the investigators adhered to the Gulding Pinciples in The Care And Use Of Animals approved by the council of The American Physiological Society. The facilities are fully accredited by the Gesundheitsbehörde der Freien und Hansestadt Hamburg. During the experimental period veterinary supervision of the animals was supplied.

Manuscript received 29 January 1982.




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