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Reduced Plasma Cholesterol Esterifying Activity in Iron-Deficient Rats: Its Possible Role in the Lipemia of Iron Deficiency^1,2,

Sushil K. Jain^°,,, Ray Yip^°, Arun K. Pramanik, Peter R. Dallman^° and Stephen B. Shohet^°

^° Cancer Research Institute and Department of Pediatrics, University of California School of Medicine, San Francisco, CA 94143 Department of Pediatrics, Louisiana State University School of Medicine, Shreveport, LA 71130

The association of iron deficiency and lipemia has been described by many investigators. However, the mechanism involved in the etiology of hyperlipidemia in iron deficiency is not known. The present communication reports that the plasma activity of lecithin:cholesterol acyltransferase, the enzyme involved in the esterification of cholesterol to cholesterol ester, is markedly diminished in iron-deficient rats, providing a possible basis for the hyperlipidemia associated with iron deficiency.

KEY WORDS: • lecithin:cholesterol acyltransferase • cholesterol esterification • hyperlipidemia • iron deficiency

¹ This work was supported in part by Grants AM 16095 and AM 13897 from the National Institutes of Health and a grant from the Hoffman-La Roche Company.

² This is publication No. 32 of the MacMillan-Cargill Hematology Research Laboratory at the University of California, San Francisco, CA.

Manuscript received 25 February 1982.