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Feeding Responses of Riboflavin-Deficient Rats to Energy Dilution, Cold Exposure and Glucoprivation

Biology Laboratories, Central Research Division, Takeda Chemical Industries, Ltd., Jusohonmachi, Yodogawa-ku, Osaka 532, Japan

Feeding, in response to various stimuli, was investigated in riboflavindeficient rats. The animals failed to increase their food intake when fed energy-diluted diets with cellulose contents of either 15 or 30%. Furthermore, they lost reactivity to the hyperphagic action of either insulin or 2-deoxy-D-glucose regardless of a perfect response in blood glucose. Cold exposure (10°), however, stimulated energy intake of the deficient rats to the same extent as that of the riboflavin-supplemented normal rats. These findings indicate that there was an operative thermostatic, but not a glucostatic control in regulation of energy intake of the riboflavin-deficient rats.

KEY WORDS: • riboflavin deficiency • anorexia • glucostatic control • thermostatic control

Manuscript received 23 December 1981.