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Journal of Nutrition Vol. 112 No. 5 May 1982, pp. 997-1002
Copyright © 1982 by American Society for Nutrition
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Role of Insulin in Food Intake, Weight Gain and Lipid Deposition in the Zucker Obese Rat1,2,

Darcie J. Stolz and Roy J. Martin

Department of Foods and Nutrition, University of Georgia, Athens, GA 30602 and Department of Animal and Dairy Science, The Pennsylvania State University, University Park, PA 16802

The role of insulin status in the development of obesity in Zucker rats was determined by equalization of available insulin. When streptozotocin-induced diabetic obese and lean rats received the same level of exogenous insulin, body weight gain and food intake per body weight were equalized. These types of observations are usually interpreted as proof for a role of insulin in genetically induced obesity. However, a more definititive examination of the composition of gain showed that the obese rat was still gaining significantly more lipid than the lean rat in spite of the equalization of availale insulin. Further examination of liver enzymes invovled in de novo lipogenesis indicated that increased hepatic lipogenesis was not dependent on hyperinsulinemia. Protein gain in lean and obese rats was not significantly different. This study demonstrates that excessive weight gain and food intake of genetically obese rats is dependent on the differences in insulin status between lean and obese rats. The partitioning of more dietary energy toward lipid in the obese rat is independent of both food intake and insulin.

KEY WORDS: • obesity • food intake • lipid synthesis

1 This work was supported by NIH grants HD 15064 and Research and Career Development Award AM00716 (to Roy J. Martin).

2 Address reprint requests to: R. J. Martin, Department of Foods and Nutrition, Dawzon Hall, University of Georgia, Athens, GA 30602.

Manuscript received 4 November 1981.




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