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Postheparin Plasma Lipoprotein Lipase in Copper-Deficient Rats

Department of Biochemistry, University of North Dakota, and U. S. Department of Agriculture, Agricultural Research Service, Grand Forks Human Nutrition Research Center, Grand Forks, ND 58202

Postheparin plasma lipoprotein lipase has been investigated in male Sprague-Dawley rats fed a diet deficient in copper. Deficiency was verified by the detection of anemia, hypercholesterolemia and decreased myocardial copper. Three experiments were done; they showed significant decrease in enzyme activity (40–47% reduction) in deficiency. Copper may be required for the formation of the activator complex of the enzyme. Decreased lipoprotein lipase activity may be responsible for the hypertriglyceridemia of copper deficiency, and that may also explain its hypercholesterolemia.

KEY WORDS: • dietary copper deficiency • lipoprotein lipase

Manuscript received 2 October 1981.

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