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Dietary Wheat Bran Lowers Colonic pH in Rats¹

Department of Internal Medicine, School of Medicine, University of California, Davis, CA 95616

The effect of chronic dietary wheat bran supplementation on the pH of gastrointestinal contents was examined in thirty-one Sprague-Dawley rats. Ten control rats received a fiber-free diet while twenty-one rats were fed the same diet plus a 20% wheat bran supplement. The fiber-fed rats developed a greater acidity of intestinal contents: cecal pH was 6.30 ± 0.07 (SEM) as compared to 6.76 ± 0.06 in the control group (P < 0.001). The effect on pH of gastric contents was the opposite, 3.90 ± 0.15 in the fiber-fed rats compared to 2.74 ± 0.33 in the controls (P < 0.01). These changes in gastrointestinal pH may be of relevance to the nutrient modulation of gastric and colonic tumor development.

KEY WORDS: • Wheat bran • dietary fiber • colonic pH • gastric pH • colonic cancer

¹ Supported by a grant from the Cancer Research Coordinating Committee, University of California.

Manuscript received 9 October 1981.

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