QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Purchase Article View Shopping Cart Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Williams, B. H. Articles by Berdanier, C. D. Search for Related Content PubMed PubMed Citation Articles by Williams, B. H. Articles by Berdanier, C. D.

Effects of Diet Composition and Adrenalectomy on the Lipogenic Responses of Rats to Starvation-Refeeding^1,2,

University of Georgia, Department of Foods and Nutrition, Dawson Hall, Athens, GA 30602

The interacting effects of diet and glucocorticoid (GC) on the tritium incorporation into lipid and glucose-6-phosphate dehydrogenase activity in starved-refed rats was studied. Male Sprague-Dawley rats were intact, adrenalectomized (ADX), or ADX and given GC and fed either ad libitum or not fed for 48 hours and refed either a 65% glucose diet, 65% sucrose diet, 65% starch diet, 65% protein diet or a 40% fat diet. No diet differences in rates of ³HOH incorporation into total lipids were observed in ad libitum-fed rats. ADX lowered lipogenesis and this effect was diet dependent. Sucrose-fed, glucose-fed and protein-fed ADX rats had lower rates of lipogenesis than their intact controls. Starvation-refeeding incrased lipogenesis in all groups of intact rats except those fed the 40% fat diet. The magnitude of the response was diet dependent. Sucrose-fed rats had greater responses than fat-fed rats. The diet effect was dependent on the presence of the adrenals and GC. Thus, the large increase in liver lipid associated with starvation-refeeding is contingent on the composition of the diet and the presence of the adrenals.

KEY WORDS: • starvation-refeeding • de novo lipogenesis • adrenalectomy • glucocorticoid

¹ Supported in part by Georgia Experiment Station Project H635 and USDA grant 5901-0410-8-0072-0.

² Data from this paper were presented at the 65th annual meeting of the Federation of American Societies for Experimental Biology, Atlants, Georgia, 1981 (abst. 4109).

³ Research conducted in partial fulfillment of the requirements for the Masters of Science degree in Foods and Nutrition. Present address: General Foods Laboratories, Cranbury, New Jersey.

⁴ To whom correspondence should be addressed.

Manuscript received 3 August 1981.

This article has been cited by other articles:

				D. P Macfarlane, S. Forbes, and B. R Walker Glucocorticoids and fatty acid metabolism in humans: fuelling fat redistribution in the metabolic syndrome J. Endocrinol., May 1, 2008; 197(2): 189 - 204. [Abstract] [Full Text] [PDF]