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Influence of Dietary Zinc on Rat Brain Catecholamines

United States Department of Agriculture Agricultural Research Service Grand Forks Human Nutrition Research Center Grand Forks, ¹ ND 58202

Weanling rats were fed a 20% sprayed egg white, zinc-deficient diet for 9 or 10 days. One group (zinc-deficient) was fed ad libitum and given distilled deionized water; a second group was individually pair-fed to rats in the zinc-deficient group; a third group was fed ad libitum; a fourth group was also fed ad libitum, but was fasted overnight prior to slaughter. The latter three groups were given 25 ppm zinc (as zinc acetate) in the water. The brain was excised and the catecholamines were extracted with 0.1 M perchloric acid, separated by reverse phase HPLC and measured electrochemically. There did not appear to be a correlation between food intake and brain catecholamine concentrations in any of the groups examined. Brain norepinephrine concentrations in the zinc-deficient rats, however, were significantly higher than in the pair-fed or ad libitum-fed rats.

KEY WORDS: • zinc deficiency • brain catecholamines • HPLC

¹ Mention of a trademark or proprietary product does not constitute a guarantee or warranty of the product by the U. S. Department of Agriculture, and does not imply its approval to the exclusion of other products that may also be suitable.

Manuscript received 23 June 1981.