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Activation of Catalase and Other Enzymes by Corn Oil Intake

Tezukayama Gakuin College, Sumiyoshi-ku, Osaka 558, Japan

The effects of linoleic acid intake on catalase and other enzymes were investigated by feeding 0, 1, 5 or 10% corn oil diet to rats previously fed a fat-free diet. Rats fed more than 1% corn oil for 2 weeks showed significant increases of glutathione peroxidase and superoxide dismutase in liver cytosol when compared to the controls fed no corn oil. Peroxisomal catalase activity especially was increased. The catalase activity was markedly increased also by ethyl linoleate intubation. Thus, it was demonstrated that the peroxide elimination mechanisms were activated by linoleic acid intake. The elevation of peroxisomal catalase by linoleic acid intake might be related to the hypolipidemic effect, similar to the possible relation between peroxisome induction and the hypolipidemic effect of many hypolipidemic compounds, which has been reported.

KEY WORDS: • linoleic acid • corn oil • glutathione peroxidase • superoxide dismutase • P-450 • catalase • peroxisomes

Manuscript received 2 June 1982.