QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Purchase Article View Shopping Cart Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Flatt, P. R. Articles by Bailey, C. J. Search for Related Content PubMed PubMed Citation Articles by Flatt, P. R. Articles by Bailey, C. J.

Role of Dietary Factors in the Hyperinsulinemia of Genetically Obese Hyperglycemic (ob/ob) Mice

Division of Nutrition and Food Science, Department of Biochemistry, University of Surrey, Guildford, Surrey GU2 5XH, U.K. and Department of Biological Sciences, University of Aston in Birmingham, Birmingham B4 7ET, U.K.

To investigate the role of different macronutrients in the hyperinsulinemia of genetically obese hyperglycemic (ob/ob) mice, we examined the insulin response of fasted adult ob/ob mice to the voluntary ingestion of foods with different protein, fat and carbohydrate compositions. During a 3-hour period after ingestion, there was a marked association between the extent of the insulin response and the rise in plasma glucose concentrations. The data suggest that dietary carbohydrate is the nutrient predominantly responsible for the severity of the hyperinsulinemia in adult ob/ob mice. The pronounced insulin-releasing effect of dietary carbohydrate in these mice cannot be attributed to a direct action of glucose on the pancreatic B cells. Thus, the results indicate an important role of the enteroinsular axis in the genesis of the marked insulin-releasing effect of dietary carbohydrate in adult ob/ob mice.

KEY WORDS: • diet • enteroinsular axis • hyperinsulinemia • obese hyperglycemic (ob/ob) mice

Manuscript received 8 June 1982.