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Factors Affecting Endogenous Oxalate Synthesis and Its Excretion in Feces and Urine in Rats¹

Tufts University School of Nutrition, Medford, MA 02155 and U.S. Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, 15 Kneeland Street, Boston, MA 02111

It has been observed that the feces as well as urine of rats fed diets supplemented with 3% glycine and 5.2% hydroxyproline contain unexpectedly high amounts of endogenously formed oxalate. That intestinal microorganisms do not synthesize significant amounts of oxalate was indicated by the findings that oral tetracycline had no effect on oxalate excretion and that germ-free rats excreted more oxalate than conventional rats. Since little intraperitoneally injected [¹⁴C]oxalate appeared in the feces, and rat intestinal mucosa homogenates were found to produce oxalate from a variety of precursors of which glyoxylic acid was by far the most important, it is probable that the intestinal mucosa may be an important source of fecal oxalate observed in these studies. Ninety percent of weanling rats fed complete diets supplemented with glycine and hydroxyproline developed urinary stones in 38 days. It has been concluded that in the treatment of patients with histories of calcium oxalate urolithiasis, more concern than is commonly shown should be directed towards the feeding of diets high in precursors of endogenous oxalate synthesis.

KEY WORDS: • oxalate • hydroxyproline • calculi

¹ Supported in part by U.S. Public Health Service Grant No. CA 23714.

Manuscript received 16 April 1982.

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