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Influence of Intraluminal Constituents on Zinc Absorption by Isolated, Vascularly Perfused Rat Intestine^1,2,

Department of Nutrition, Rutgers University, New Brunswick, NJ 08903

An isolated, vascularly perfused rat intestine system was utilized to compare the influence of a variety of potential zinc-binding compounds on zinc absorption. Citric acid, cysteine, reduced glutathione, histidine, methionine, picolinic acid and tryptophan were added to the lumen perfusate at 110 µM. Two lumen perfusate pH values (4.2 and 6.6) were compared. The influence of EDTA at pH 6.6 was also investigated as was the influence of citric acid, histidine, picolinic acid and tryptophan additions to the lumen perfusate at 550 µM. Of the substances tested only EDTA significantly enhanced the transfer of zinc from the lumen to the portal circulation. These results suggest these potential zinc chelators, exclusive of EDTA, do not promote zinc absorption by the intestine in this system.

KEY WORDS: • intestine • absorption • zinc • chelators

¹ Supported by grant no. AM 18555 from the National Institute of Arthritis, Diabetes, Digestive and Kidney Diseases and as Project No. 14112 of the New Jersey Agricultural Experiment Station.

² Presented in part at the American Institute of Nutrition Meeting. Atlanta, GA, April 1981, Fed. Proc. 40, 937 (abs.).

³ Present address: Department of Food Science and Human Nutrition, University of Florida, Gainesville, FL 32611.

⁴ To whom reprint requests and correspondence should be addressed.

Manuscript received 16 June 1982.