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Journal of Nutrition Vol. 112 No. 1 January 1982, pp. 151-157
Copyright © 1982 by American Society for Nutrition
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Biological Effects of Substituting Enriched 54Fe for Natural Iron in Rats1,2,

Brian R. Schricker3, Mason D. Gilbert4, Dennis D. Miller5 and Darrell Van Campen6

Department of Food Science, Cornell University, Ithaca, New York and U. S. Plant, Soil, and Nutrition Laboratory, Ithaca, New York

The effect of feeding an enriched stable isotope of iron, 54Fe, to rats was examined. Weanling rats were fed semisynthetic diets in which 54Fe was substituted for all added natural iron for a period of 21 days. Growth; feed conversion; total liver, spleen, and femur iron; serum iron and hemoglobin concentrations; hematocrit; RBC and WBC volume; FEP concentration; kidney and heart aconitase activities; erythrocyte and liver catalase activities; liver microsomal oxidase activity; and pathological lesions did not differ between control and 54Fe enriched animals. Based on the biochemical and histological parameters examined in this study an isotope effect of 54Fe was not observed.

KEY WORDS: • iron • iron-54 • stable isotope • isotope effect

1 Supported by the Institute of Food Science, New York State College of Agriculture and Life Sciences, Cornell University, and the U. S. Plant, Soil and Nutrition Laboratory, SEA, USDA, Ithaca, New York.

2 Address reprint requests to: Dennis D. Miller, Department of Food Science, Stocking Hall, Cornell University, Ithaca, New York 14853.

3 Research associates and assistant professor, respectively. Department of Food Science, Cornell University.

4 Research associates and assistant professor, respectively. Department of Food Science, Cornell University.

5 Research associates and assistant professor, respectively. Department of Food Science, Cornell University.

6 Laboratory Director, U. S. Plant, Soil and Nutrition Laboratory.

Manuscript received 26 May 1981.




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