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Dietary Effects on Metabolism of Yucatan Miniature Swine Selected for Low and High Glucose Utilization

Department of Physiology and Biophysics and Department of Anatomy, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, CO 80523

Yucatan miniature swine have been selected for increased (high K) or decreased (low K) ability to utilize glucose based on an intravenous glucose tolerance test (IVGTT). In this study we tested the effect of obesity in conjunction with ad libitum, high sucrose or high starch diets on IVGTT and the insulin response to glucose in these two lines of animals. Either diet caused increased glucose utilization and an increased insulin response in the low K animals. Neither diet caused a change in these parameters in the high K pigs. There were no differences in either line of animals due to sucrose vs starch diets. During an insulin impedance test both the mean steady state plasma glucose and plasma serum insulin concentrations were significantly higher in the high K animals (P < 0.01).

KEY WORDS: • insulin • glucose tolerance • miniature swine • sucrose • starch

Manuscript received 22 January 1981.