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Journal of Nutrition Vol. 111 No. 9 September 1981, pp. 1681-1685
Copyright © 1981 by American Society for Nutrition
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Self-Regulation of Phosphate Intake by Growing Rats1

G. M. Siu, M. Hadley and H. H. Draper

Department of Nutrition, College of Biological Science, University of Guelph, Guelph, Ontario, Canada N1G 2W1

Groups of growing rats (100–150 g) were offered a choice of two diets, one containing a deficient concentration of phosphorus (0.1%) and the other containing 0.3, 0.6, 1.2 or 1.8% phosphorus. All diets contained 0.6% Ca and were isocaloric. Except for the groups that were offered the 0.1 and 0.3% phosphorus diets, all the animals selected mixtures of diets containing nearly identical phosphorus contents (0.33–0.36%). The group offered the two diets lowest in phosphorus selected 83% of their food from the higher (0.3%) phosphorus diet to obtain a mixture containing 0.25% phosphorus. Irrespective of the phosphorus content of the diets available, all groups ate similar amounts of food, made similar weight gains and maintained normal plasma levels of calcium and phosphorus. The experiment demonstrates the existence of a feedback mechanism by which growing rats regulate their phosphorus intake within narrow limits when allowed to self-select among diets of markedly different phosphorus contents. It is postulated that feedback regulation of phosphorus intake is mediated by changes in plasma calcium homeostasis.

KEY WORDS: • phosphate intake • self-regulation • rats

1 Supported by the Ontario Ministry of Agriculture and Food and The Natural Sciences and Engineering Research Council.

Manuscript received 26 January 1981.




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