QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Purchase Article View Shopping Cart Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Skapski, B. Articles by Swendseid, M. E. Search for Related Content PubMed PubMed Citation Articles by Skapski, B. Articles by Swendseid, M. E.

Influence of Protein Intake on S-Adenosyl Methionine Decarboxylase Activity in Normal and Chronically Uremic Rats^1,2,

School of Public Health, University of California, Los Angeles, CA 90024

The activity of S-adenosyl methionine decarboxylase (SAM decarboxylase), an enzyme mediating polyamine biosynthesis, was measured in liver and kidney of chronically uremic rats and their pair-fed controls. Effects of protein intake were assessed in groups of rats fed either 8 or 18% casein or switched from 18 to 70% casein for 14 hours. In control rats, both hepatic and renal SAM decarboxylase activities increased with the higher levels of dietary casein. In uremic rats, SAM decarboxylase activity was not responsive to alterations in protein intake. Hepatic and renal SAM decarboxylase activity was significantly higher in control rats than in uremic rats, but this was due to increases in activity that occurred with diets containing higher amounts of protein (18 and 70% casein versus 8% casein).

KEY WORDS: • S-adenosyl methionine decarboxylase • liver • kidney • uremia

¹ Supported by NIH grant AM15197.

² Preliminary results of some of this work have been presented: Skapski, B. & Swendseid, M. E. (1978) S-Adenosyl methionine decarboxylase activity in uremia. Fed. Proc. 37, 751.

Manuscript received 22 December 1980.