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Effect of High Dietary Glutamic Acid on the Excretion of ³⁵S-Thiamin in Kittens¹

Department of Physiological Sciences, School of Veterinary Medicine and Department of Animal Sciences, University of California, Davis, CA 95616

Six kittens individually housed in stainless steel metabolism cages were fed a control diet containing 3% glutamic acid (Glu) for 2 weeks and then subsequently for 12 weeks were fed a 12% Glu diet. All diets contained 4.4 mg thiamin/kg diet. The 12% Glu diet significantly depressed weight gain during the first 6 weeks and food intake during the 3rd and 4th weeks of dietary regimen as compared to the control period. Plasma levels of Glu increased with the duration of the 12% dietary regimen. On days 0, 14, 28 and 42, the kittens were given a 4 g meal containing 10 µCi of ³⁵S-thiamin. Although the mean excretion of isotope in the feces, calculated as a percentage of the ingested dose, was about 25% greater in the first 2 weeks of the 12% Glu dietary regimen than the control period, the difference was not significant. Urinary excretory rate of ³⁵S-thiamin was depressed during the first 4 weeks of the 12% dietary regimen. When exponential relationships were fitted to the excretion data, the coefficients for the first and second 2-week intervals of the 12% Glu dietary regimen were –0.177 and –0.167, respectively, compared to –0.199 and –0.212 obtained for the control period and the third 2-week interval of the high Glu dietary regimen, respectively.

KEY WORDS: • thiamin excretion • glutamic acid intolerance • kittens

¹ Supported in part by a gift from The Carnation Co., Los Angeles, CA.

² To whom reprint requests should be sent: Department of Physiological Sciences, University of California, Davis, CA 95616.

Manuscript received 15 September 1980.