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Bioavailability of some Lysine Derivatives in Mice

Western Regional Research Center, Agricultural Research Service U.S. Department of Agriculture, Berkeley, Ca. 94710

Growth assays using mice on synthetic amino acid diets showed that substituting -N-methyl-L-lysine, -N-dimethyl-L-lysine and -N-trimethyl-L-lysine for lysine resulted in relative replacement values about 1/12, 1/20 and 1/25, respectively, of that obtained with the standard lysine diet. Similar studies showed that the -N-acetyl-L-lysine is not utilized by mice and that the relative the replacement value of -N-acetyl-L-lysine was about 3% of that of lysine. Analogous substitution of D-lysine and the lysine sulfur-containing analog, S-(2-aminoethyl)-L-cysteine, for lysine resulted in weight losses during the feeding period. The results are discussed with reference to factors that are expected to influence the biological utilization of lysine analogs and derivatives.

KEY WORDS: • bioavailability • lysine derivatives • mice

Manuscript received 13 January 1981.