Journal of Nutrition

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Journal of Nutrition Vol. 111 No. 3 March 1981, pp. 537-544
Copyright © 1981 by American Society for Nutrition
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Effect of Fluoride on the Absorption of Dietary Fat in Rats1

Robin Schnitzer-Polokoff2 and John W. Suttie

Department of Biochemistry, College of Agricultural and Life Sciences, University of Wisconsin-Madison, Madison, WI 53706

The inhibition of lipid absorption by sodium fluoride in adult male rats was investigated following intraduodenal infusion of labeled lipid and cannulation of the intestinal lymphatics. A striking delay in both the appearance and total amount of lymph radioactivity was observed when 26 mM fluoride was included in the infusate. Effective inhibition of lipid absorption was observed over a 15-fold wide range of fluoride concentration (3.3–56 mM). The inhibitory effect of fluoride was not due to an inhibition of lipolysis since the absorption of free palmitic acid was inhibited to the same extent as that of tripalmitoyl glycerol. Studies on the uptake and distribution of infused lipid in the upper small intestine and experiments examining the extent of fluoride-induced absorptive inhibition of different fatty acids suggest that the effect of fluoride may be on the mucosal reesterification of dietary lipid.

KEY WORDS: • fluoride • lipid absorption • mucosal reesterification

1 Supported in part by the College of Agriculture and Life Sciences, University of Wisconsin-Madison, and in part by grant AM-15521 from the NIH-USPHS, and Environmental Toxicology Training Grant 2T 32E S07015 from the NIH-USPHS.

2 Present address: Eleanor Roosevelt Institute, University of Colorado Medical Center, 4200 East Ninth Ave., Denver, CO 80220.

Manuscript received 31 July 1980.




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