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Composition of Rat Milk from Day 5 to 20 of Lactation and Milk Intake of Lean and Preobese Zucker Pups^1,2,

Department of Nutrition, Harvard School of Public Health, Boston, MA 02115

Milk composition and milk intake were measured in lean and preobese Zucker rat pups. Lactating dams were injected with ³H₂O, which equilibrated with plasma water within 30 minutes. A constant specific activity of ³H was maintained by adding ³H₂O to drinking water. Blood samples of 5 µl were obtained from 10, 15 and 20-day-old suckling pups every 4 hours for a 24-hour period and the accumulation of tritium was used to calculate pups' milk intake. No diurnal variation in milk intake of pups was observed. Obese pups were identified at 5 weeks of age and showed no difference in milk intake compared to lean littermates at 10, 15 and 20 days of age. Milk intake of pups increased with age from 2.0 ml at day 10 to 15.8 ml by day 20. Food and water intake of dams also increased from day 10 to 20 of lactation. The protein and carbohydrate component of rat milk did not change significantly from day 5 to 20 of lactation; however, the fat component decreased significantly from 12.7% at day 5 to 4.2% at day 20.

KEY WORDS: • Zucker fatty rats • milk composition • milk intake

¹ Research was supported by National Institutes of Health grants AM 02911 and AM 00106 and the Fund for Teaching and Research, Department of Nutrition.

² Preliminary report presented at the annual meeting of the Federation of American Societies for Experimental Biology, Anaheim, CA, 16 April 1980. Godbole, V. Y., Grundleger, M. L., Pasquine, T. A. & Thenen, S. W. (1980) Composition of dam's milk and milk intake of lean and preobese (fa/fa) Zucker rats. Fed. Proc. 39, 887 (abs.).

Manuscript received 7 July 1980.

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