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Pair-Feeding in the Dietary Control of Glucose-6-Phosphate Dehydrogenase¹

Oklahoma Medical Research Foundation and Department of Biochemistry and Molecular Biology, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104

The great increase ("overshoot") in glucose-6-phosphate dehydrogenase activity in liver cytoplasm which follows the transfer of rats from starvation to a high sucrose diet has been recognized for a number of years. Also the fact that transferring fed rats to the high sucrose diet results only in a small increase in G6PD activity while transfer of "starved" rats to the high sucrose diet results in a 10 to 20-fold ("overshoot") increase in G6PD activity is equally recognized. This report demonstrates that the "overshoot" following 4 days without food is not due to an increase in food intake compared to the food intake of fed rats since pair-feeding during this refeeding at three different levels does not eliminate the effect of the prior fast.

KEY WORDS: • glucose-6-phosphate dehydrogenase • dietary sucrose • starvation • enzyme overshoot

¹ This research was supported in part by NIH Grant No. HL-12138.

² Fellow of the Consejo Nacional de Investigaciones Cientificos y Tecnicas de la Republica Argentina. On leave from the Universidad de San Luis.

³ To whom reprint requests should be sent.

Manuscript received 6 June 1980.