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Journal of Nutrition Vol. 111 No. 11 November 1981, pp. 2034-2038
Copyright © 1981 by American Society for Nutrition
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Interaction Between Zinc Deprivation and Acute Ethanol Intoxication During Pregnancy in Rats

Russell E. Ruth and Sara K. Goldsmith

Institute for the Study of Developmental Disabilities, University of Illinois, Chicago Circle, Chicago, IL 60608

A single intraperitoneal injection of ethanol given at gestational day 10 to pregnant rats undergoing transient zinc deprivation increases the probability of complications in the pregnancy, compared to either intoxication in well-fed dams or to zinc deprivation alone. The results suggest that dietary factors may contribute to ethanol-induced terata and that non-abusive or infrequent maternal use of ethanol can be particularly dangerous to the fetus during a dietary deficiency.

KEY WORDS: • zinc deprivation • pregnancy • ethanol

Manuscript received 21 July 1981.




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