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Decreased Bile Acid Pool in Neonates of Guinea Pigs Fed Cholesterol during Pregnancy^1,2,

Departments of Pathology and Medicine, University of Cincinnati Medical Center, Cincinnati, OH 45267

Feeding 0.25% cholesterol-containing chow to guinea pigs during pregnancy resulted in a) significantly higher plasma cholesterol in the neonates, b) a striking decrease in the total bile acid pool of the neonates, with a significant reduction in the pool of chenodeoxycholic acid, and c) an increase in the proportion of bile acids associated with the neonatal liver. These results suggest that feeding cholesterol to guinea pigs during pregnancy has undesirable effects in the neonate in terms of the development of cholesterol degradation mechanisms.

KEY WORDS: • Cholesterol feeding • pregnancy • bile acid pool • neonate • plasma cholesterol

¹ Supported in part by grant #HL-24263 from the National Heart, Lung and Blood Institute.

² Paper 10 in the series, "Sterol and Bile Acid Metabolism During Development." Reference 18 is paper 9 in this series.

Manuscript received 29 June 1981.