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Effect of Malnutrition During Pregnancy on the Development of the Mammary Glands of Rats

Department of Pediatrics, Babies Hospital and Institute of Human Nutrition, College of Physicians and Surgeons, Columbia University, 701 West 168th St., New York, NY 10032

Sprague-Dawley rats fed 50% of normal food intake from day 5 of gestation had a marked reduction in the weight of their left mammary glands compared with control nonrestricted animals. The affected glands had a significant reduction in DNA, RNA and protein content. Protein/DNA ratio was also reduced while RNA/DNA ratio was unchanged. Histological studies of the glands revealed a reduced number of parenchymal cells, reduced cell size and larger lumen within the alveoli.

KEY WORDS: • malnutrition • mammary glands

¹ Visiting scientist from Department of Nutrition and Food Hygiene, Institute of Health, Chinese Academy of Medical Sciences, Beijing, People's Republic of China.

Manuscript received 13 April 1981.