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Journal of Nutrition Vol. 111 No. 10 October 1981, pp. 1704-1710
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Hepatic Metabolites and Amino Acid Levels during Adaptation of Rats to a High Protein, Carbohydrate-Free Diet1

Jean Peret2,*, Sana Foustock*, Marc Chanez*, Brigitte Bois-Joyeux* and James L. Robinson{dagger}

* Centre de Recherches sur la Nutrition du C.N.R.S., 9 rue Jules Hetzel, 92190 Meudon-Bellevue, France, {dagger} Department of Dairy Science, University of Illinois, Urbana, IL 61801

Changes in hepatic levels of lactate, pyruvate, phosphoenolpyruvate (PEP), {alpha}-ketoglutarate, malate, oxaloacetate, ketone bodies, alanine, serine, glycine, aspartate, glutamate, glutamine, valine, urea, adenine nucleotides and inorganic phosphate were examined in rats consuming a high protein, carbohydrate-free diet for up to 40 days. While some components showed transient changes, others (pyruvate, malate, oxaloacetate, PEP, ketone bodies, alanine, glycine, glutamine, valine, urea, adenine nucleotides and inorganic phosphate) were permanently altered. The cytoplasmic and mitochondrial redox states were only transiently affected and by day 24 were not different from control values. In contrast, the cytoplasmic phosphorylation state was affected from day 1 on; this suggests a role for the latter in permanently reorienting metabolism toward gluconeogenesis and ureogenesis.

KEY WORDS: • protein • hepatic metabolites • amino acids

1 Represents part of a doctoral thesis submitted by S. Foustock to the University of Paris VI.

2 To whom reprint requests should be sent (France).

Manuscript received 20 February 1981.




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