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Glucose and Lactate Absorption and Metabolic Interrelationships in Lambs Switched from Low to High Concentrate Diets^1,2,

Roman L. Hruska U.S. Meat Animal Research Center, Clay Center, NE 68933³ and Animal Science Department, University of Nebraska, Lincoln, NE 68503

Two experiments were conducted to measure glucose and lactate absorption and metabolic interrelationships in lambs either switched gradually (experiment 1) or abruptly (experiment 2) from hay to a high concentrate diet. In experiment 1, seven lambs were given primed, continuous, 3-hour infusions of 2-[³H]glucose, U-[¹⁴C]L-lactate and para-aminohippuric acid (portal blood flow indicator) before and after switching from a pelleted hay to a pelleted, 85% concentrate diet. Blood samples were collected at 20-minute intervals during infusions. In experiment 2, four lambs were abruptly switched from a pelleted hay to an all-concentrate diet. Portal and arterial blood samples were collected before and up to 1 week after the diet switch. As a result of increased concentrate intake (experiment 1) net portal absorption and turnover of L-lactate and glucose increased. Percentage of glucose derived from L-lactate decreased. Net portal D-lactate absorption, L-lactate absorption as a percentage of turnover and conversion of L-lactate to glucose were not affected by diet. Lambs in experiment 2 did not become acutely acidotic. The insult to acid-base status peaked 12–16 hours after the diet switch, concurrent with maximum arterio-venous differences in plasma L-lactate and glucose. Arterio venous differences in plasma D-lactate were not significantly affected.

KEY WORDS: • lambs • glucose • lactate

¹ Portions of data included herein were presented in an abstract: Huntington, G. B., Prior, R. L. and Britton, R. A. (1979) Dietary concentrate level affects absorption rates and metabolism of lactate and glucose in sheep. Fed. Proc. 38, 769 (abs.).

² Published as paper No. 5890, Journal Series, Nebraska Agriculatural Research Station.

³ Roman L. Hruska U. S. Meat Animal Research Center, Agricultural Research Service, Mention of a trade name, proprietary product or specific equipment does not constitute a guarantee or warranty by the U.S. Department of Agriculture and does not imply its approval to the exclusion of other products that may be suitable.

Manuscript received 10 December 1979.