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Journal of Nutrition Vol. 110 No. 9 September 1980, pp. 1813-1818
Copyright © 1980 by American Society for Nutrition
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Effect of Cholecalciferol and 1,25-Dihydroxycholecalciferol on the Intestinal Absorption of Zinc in the Chick1

Sung I. Koo2, Curtis S. Fullmer and Robert H. Wasserman3

Department of Physical Biology, New York State College of Veterinary Medicine, Cornell University, Ithaca, NY 14853

The effect of cholecalciferol on the intestinal absorption of 65Zn was assessed in zinc-deficient and zinc-replete rachitic chicks, using the in situ ligated loop techniques. Cholecalciferol did not significantly affect 65Zn absorption in either group, although the synthesis of the intestinal calcium-binding protein (CaBP) in both groups was similar. In an analogous study, 1,25-dihydroxycholecalciferol increased 47Ca absorption and induced the synthesis of CaBP but exerted no effect on 65Zn absorption in zinc-deficient rachitic chicks. When fed a diet adequate in cholecalciferol, more CaBP was present in the intestine of the zinc-adequate group than in the zinc-deficient group, possibly due to the greater rate of growth and therefore the greater need for calcium by the former group. These results suggest that cholecalciferol and its most active metabolite do not directly affect zinc absorption and, by inference, that the vitamin D-dependent transport mechanism is not involved in zinc homeostasis, or in the interaction between calcium and zinc.

KEY WORDS: • absorption • zinc • cholecalciferol

1 Supported by DOE Contract No. EY-76-S-02-2792 and NIH Grant AM-04652.

2 Present address: School of Medicine and Dentistry, Oral Roberts Univ. Tulsa, OK 74171.

3 To whom reprint requests should be sent.

Manuscript received 5 February 1980.




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