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Effect of Dietary Level of Protein on Liver Microsomal Drug-Metabolizing Enzymes, Urinary Ascorbic Acid and Lipid Metabolism in Rats Fed PCB-Containing Diets¹

Department of Agricultural Chemistry, Nagoya University, Nagoya 464, Japan

Effects of dietary level of protein on liver microsomal drug-metabolizing enzyme system, lipids and urinary ascorbic acid metabolism were studied in the rats fed 0.1% polychlorinated biphenyl (PCB) containing diets. In the rats not receiving PCB, the activity of the enzyme system increased as the protein level was increased up to around 35%. In a short-term experiment (8–9 days), dietary PCB caused an increase in the activity of the enzyme system regardless of dietary level of protein. In a semi-long term experiment (29–30 days), however, 35–55% protein diets did not allow for induction to the same extent. As a result the highest activity was observed with 10–20% protein diets in this period. The increments in urinary ascorbic acid and in serum cholesterol were generally potentiated with high-protein diets. Maximum increments in urinary ascorbic acid and serum cholesterol were obtained with 20% protein and 35% protein, respectively, in the semi-long term experiment. In contrast to serum cholesterol, the accumulation of liver cholesterol and triglyceride due to PCB was markedly potentiated with low-protein diets.

KEY WORDS: • PCB • dietary protein • drug-metabolizing enzyme • urinary ascorbic acid • serum cholesterol • liver lipids

¹ Supported in part by the grant of Vitamin C Research Committee in Japan.

Manuscript received 10 December 1979.