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Reduction of Lipogenic Enzymes by Shellfish Triglycerides in Rat Liver

Tezukayama Gakuin College, Sumiyoshi-ku, Osaka 558, Japan

When rats were fed for 2 weeks on 3% fat diets containing 0.5 or 1% corbicula (Corbicula japonica PRIME), clam (Tapes japonica) or oyster (Callocorchina) triglycerides, serum and liver triglyceride levels were significantly lowered. The activities of hepatic glucose-6-phosphate dehydrogenase, malic enzyme and acetyl-CoA carboxylase were markedly reduced in the rats. Cholesterol synthesis by liver slices was also reduced. The results of immunochemical titrations and Ouchterlony double-diffusion analysis indicated that the decreases in the activities of acetyl-CoA carboxylase and glucose-6-phosphate dehydrogenase were due to decreases in the enzyme quantities. The shellfish triglycerides include a high percentage of long chain and polyunsaturated fatty acids, which are common to and characteristic of the three kinds of shellfish. They would be effective components in these observations.

KEY WORDS: • shellfish triglycerides • triglyceride levels • lipogenic enzymes • enzyme quantity

¹ Present address: Endocrine and Metabolic disease Research Center, Kyoto National Hospital, Kyoto, Japan.

Manuscript received 13 November 1979.