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Journal of Nutrition Vol. 110 No. 8 August 1980, pp. 1648-1654
Copyright © 1980 by American Society for Nutrition
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Target Organ Pathology in Iron-Deficient Suckling Rats1

Hans Rothenbacher and Adria Rothman Sherman2

Department of Veterinary Science and Nutrition Program, The Pennsylvania State University, University Park, PA 16802

Pathological changes in 18-day-old rat pups from iron-deficient dams (5 ppm dietary iron) included severe fatty degeneration of the liver with focal hepatocellular necrosis plus complete depression of hemopoiesis in this organ. Similar fatty degeneration occurred in the cortical tubular epithelial cells of the kidneys of deficient rats. Lesions in spleens and thymuses of the iron-deficient rat pups indicate depression of hemopoiesis and lymphopoiesis of both thymus-dependent lymphocyte (T-cell) and bursa-equivalent lymphocyte (B-cell) areas. From the qualitative and quantitative evaluation of thymus and spleen it may be concluded that the iron-deficient young rats are immunologically retarded and/or are permanently less competent than the controls.

KEY WORDS: • iron-deficiency • anemia • histopathology

1 This investigation was supported in part by grants from the National Institutes of Health, Heart, Lung and Blood Institute (HL 18712-03) and a College of Human Development Faculty Research Fund Grant to Dr. Sherman. Approved by the director of the Pennsylvania Agriculture Experiment Station as a paper no. 5577 in the journal series.

2 To whom reprint requests should be sent at present address: Department of Foods and Nutrition, University of Illinois, Urbana, IL 61801.

Manuscript received 7 January 1980.




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