Journal of Nutrition

Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
QUICK SEARCH:   [advanced]


     

Journal of Nutrition Vol. 110 No. 8 August 1980, pp. 1641-1647
Copyright
This Article
Right arrow Full Text (PDF)
Right arrow Purchase Article
Right arrow View Shopping Cart
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Sasser, L. B.
Right arrow Articles by Jarboe, G. E.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Sasser, L. B.
Right arrow Articles by Jarboe, G. E.

Intestinal Absorption and Retention of Cadmium in Neonatal Pigs Compared to Rats and Guinea Pigs1

L. B. Sasser and G. E. Jarboe

Comparative Animal Resarch Laboratory 1299 Bethel1 Valley Road, Oak Ridge, TN 37830

The purpose of this study was to measure intestinal absorption and retention of cadmium in the newborn pig and to compare data from the pig, rat and guinea pig, three species that differ greatly in their ability to absorb macromolecules at birth. Newborn pigs were administered a single oral dose of 50 µCi of 115mCd (0.20 mCi/mg Cd) 24 hours after birth and killed at intervals between 1 and 14 days after dosing. Cd absorption and gastrointestinal retention were then determined; these data were compared with similar data from the rat and guinea pig. The cumulative Cd absorption was about 4.0, 5.0 and 23% of the dose in the day-old pig, rat and guinea pig, respectively. The residence time of Cd in the intestinal tract was longer in the rat than in the pig or guinea pig, the 50% excretion time being 15, 8 and 5 days in the rat, pig and guinea pig, respectively. Cd absorption in the neonate appears to be a two-step process: mucosal uptake of Cd from the lumen, probably by pinocytosis, followed by transfer of a portion of this Cd into the body. This transfer process is similar, but does not entirely coincide with changes associated with protein absorption in the neonate.

KEY WORDS: • neonate • intestine • absorption • cadmium

1 Research supported by U.S. Department of Energy Contract No. DE-AC05-760R00242 with The University of Tennessee.

Manuscript received 5 November 1979.




Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]