Journal of Nutrition Animal Diets/Enrichment Products...

Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
QUICK SEARCH:   [advanced]


     

Journal of Nutrition Vol. 110 No. 7 July 1980, pp. 1372-1379
Copyright © 1980 by American Society for Nutrition
This Article
Right arrow Full Text (PDF)
Right arrow Purchase Article
Right arrow View Shopping Cart
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Gabriel, E.
Right arrow Articles by Nelson, J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Gabriel, E.
Right arrow Articles by Nelson, J.

Influence of Age on the Vitamin E Requirement for Resolution of Necrotizing Myopathy

Edda Gabriel{dagger}, L. J. Machlin, R. Filipski* and J. Nelson**

{dagger} Roche Research Center, Department of Biochemical Nutrition, Nutley, NJ 07110 * Roche Diagnostics, Hoffmann-La Roche Inc., Belleville, NJ 07109 and Department of Pathology and Pediatrics, Washington University School of Medicine, St. Louis, MO 63110

Weanling rats were fed either a vitamin E-deficient diet or the deficient diet supplemented with vitamin E or the antioxidant ethoxyquin. Ethoxyquin was not effective in preventing the elevation in platelet number or percent aggregation. However, ethoxyquin was as effective as vitamin E in maintaining body weight, testes weight, pigmentation of the incisors and in preventing myopathy, observed either histologically or by an elevation in plasma glutamic oxalacetic transaminase (GOT) activity. Removal of ethoxyquin from the diet after 19 weeks of feeding resulted in a rapid onset of myopathy. These observations permitted us to study the requirement for vitamin E at various ages without the complication of any cumulative pathological effects of vitamin E deficiency. Ethoxyquin was deleted from the diet at 8, 20, 44 and 64 weeks of age. The requirement for vitamin E to reduce plasma GOT and pyruvate kinase (PK) activity was measured at 12, 24, 48 and 68 weeks of age. The requirement for vitamin E did not change significantly during this time period.

KEY WORDS: • vitamin E • ethoxyquin • age • necrotizing myopathy

Manuscript received 6 December 1979.




Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]