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Effect of Food Intake on Hypermetabolic Response to Burn Injury in Guinea Pigs¹

Departments of Surgery and Pediatrics, Harvard Medical School, Massachusetts General Hospital and Shriners Burns Institute, 51 Blossom St., Boston, MA 02114

We have studied the effect of caloric intake on metabolic rate in normal and burned (20–25% body surface area, BSA) guinea pigs. Food intake was standardized by means of infusing a liquid diet (48 kcal/day) through chronic gastrostomy tubes continuously for 16 hours per day. We found that feeding control animals a diet insufficient to meet their daily caloric requirements nevertheless resulted in a significantly higher basal oxygen consumption (
O₂) 8 hours after food than during fasting. The incremental increase in basal
O₂ induced by feeding burned animals (20–25% BSA) was even greater than in controls. Thus, although basal
O₂ was similar in control fasted and burned-fasted animals, basal VO₂ in burned-fed animals was significantly greater than in control-fed animals.

KEY WORDS: • oxygen consumption • catecholamines • T₄ • T₃ • guinea pigs

¹ Supported by NIH Grant GM 21700-05.

² Supported by NIH-RCDA GM 00455-1.

Manuscript received 2 January 1980.