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Effect of Dietary Phytate/Zinc Molar Ratio on Growth and Bone Zinc Response of Rats Fed Semipurified Diets¹

Vitamin and Mineral Nutrition Laboratory, Nutrition Institute, Human Nutrition Center, Science and Education Administration, United States Department of Agriculture, Beltsville, MD 20705

In rats fed semipurified diets, bioavailability of dietary zinc was tested at different phytate/zinc molar ratios; growth and zinc in femurs were the criteria of adequacy. On diets with 10–12 ppm zinc, the growth of rats was not affected by phytate/zinc molar ratios of 12 or less if the level of dietary calcium was 0.75% but was depressed at ratios greater than 6 if the level of calcium was 1.75%. Phytate/zinc molar ratios greater than these did not depress growth if the dietary zinc concentration was at least 2.5 and 5 times the minimal requirement for growth at dietary calcium levels of 0.75 and 1.75%, respectively. At the maximum phytate/zinc molar ratio that did not depress growth, accumulation of zinc in femurs was depressed. Small increases in dietary calcium (from 0.75 to 0.87%) depressed growth of rats fed diets with 12 ppm zinc and a phytate/zinc molar ratio of 25. Preformed Zn₃ and Zn₆ phytate preparations were equivalent to ZnSO₄·7H₂O as dietary zinc sources. The data indicated that high dietary calcium per se reduced zinc bioavailability. The maximum phytate/zinc molar ratio that did not depress growth of young rats was greatly influenced by dietary calcium level and somewhat influenced by total dietary zinc concentration.

KEY WORDS: • zinc bioavailability • phytate/zinc molar ratio • phytate

¹ Presented in part at the 10th National Conference on Wheat Utilization Research, Tucson, AZ, Nov. 1977, ARM-W-4 (Saunders, R. M., ed.) pp. 51–62, Office Regional Administrator for Federal Research, SEA, USDA, Berkeley, CA 94705 and at the 12th Annual Conference on Trace Substances in Environmental Health, University of Missouri, Columbia, MO. June 1978.

Manuscript received 30 October 1979.

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