Journal of Nutrition

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Journal of Nutrition Vol. 110 No. 3 March 1980, pp. 591-593
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Low Zinc Concentration in Rat Uterine Fluid After 4 Days of Dietary Deficiency1

Daniel Gallaher and Lucille S. Hurley

Department of Nutrition, University of California, Davis, CA 95616

Pregnant rats were fed a purified diet either complete (100 ppm zinc) or zinc-deficient (0.4 ppm zinc) from the day of mating (day 0). On day 4 of pregnancy, the zinc concentration of uterine fluid in rats fed the deficient diet was only half that of controls, although protein concentration was the same. It is proposed that the low concentration of uterine fluid zinc is responsible for the abnormal development of preimplantation embryos reported earlier under these conditions.

KEY WORDS: • zinc • uterine fluid • embryonic development

1 This research was supported in part by National Institutes of Health Research Grant HD-01743 from the National Institute of Child Health and Human Development.

Manuscript received 26 December 1979.




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