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Journal of Nutrition Vol. 110 No. 3 March 1980, pp. 496-504
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The Relative Response of Hepatic Lipids in the Rat to Graded Levels of Dietary Myo-Inositol and Other Lipotropes1

D. B. Andersen and B. J. Holub

Department of Nutrition, College of Biological Science, University of Guelph, Guelph, Ontario N1G 2W1, Canada

Hepatic triglyceride (TG) accumulation appeared to vary inversely up to a point with the level of dietary myo-inositol in the absence of dietary choline, and each of the major fatty acids of liver TG was similarly affected. Although the composition of the major fatty acids changed little, 16:1 was generally higher and 18:0 lower in the liver TG of myo-inositol-deficient rats. Furthermore, both the level and the fatty acid composition of non-esterified fatty acids (NEFA) in liver changed dramatically. Supplementation of diets containing myo-inositol or choline with DL-methionine (0.2% by weight) did not significantly influence hepatic TG concentrations. Even when choline was present in the diet at the National Research Council (NRC) requirement (5.4 mmol/kg diet), supplementary myo-inositol decreased further liver TG levels below the levels achievable with choline alone. Dietary myo-inositol was as efficient as choline on a molar basis in preventing the accumulation of TG in liver when compared at 5.4 mmol/kg diet.

KEY WORDS: • myo-inositol deficiency • hepatic triglyceride • liver non-esterified fatty acid • free fatty acid • choline deficiency • lipotrope

1 Supported by funds from the Natural Sciences and Engineering Research Council of Canada.

Manuscript received 9 July 1979.




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