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Myo-Inositol-Responsive Liver Lipid Accumulation in the Rat¹

Department of Nutrition, College of Biological Science, University of Guelph, Guelph, Ontario, Canada N1G 2W1

A nutritionally acceptable diet, with all nutrients at or above their known requirements, was found useful for studying the myoinositol-responsive lipid accumulation in young rats. Succinyl sulfathiazole supplementation of the diet was judged unnecessary to produce increases in the concentration of hepatic triglycerides (TG). The TG accumulation appeared to decrease somewhat after reaching maximal levels under conditions of myo-inositol deficiency in young rats, whereas the accumulation was not observed in older animals. Both young male and female rats responded to dietary myo-inositol when supplemented at a level similar to the level of myo-inositol in the human diet.

KEY WORDS: • myo-inositol deficiency • hepatic triglyceride • choline deficiency • lipotrope

¹ Supported by a grant from the Natural Sciences and Engineering Research Council of Canada.

Manuscript received 9 July 1979.