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Effects of Prolonged Starvation on Plasma Free Fatty Acid Levels and Fatty Acid Composition of Myocardial Total Lipids in the Rat¹

Steven Yaffe^2,*, Armand Gold^3,* and Joseph Sampugna

^* Department of Physiology and Biophysics, Howard University College of Medicine, Washington, DC 20059 and Department of Chemistry, University of Maryland, College Park, MD 20740

Experiments were carried out on male rats fed a libitum or starved for a period of 7 days. Plasma levels of free fatty acids (FFA) and the quantity and composition of fatty acids in total lipids of heart ventricular tissue in vivo were analyzed by gas liquid chromatography (GLC). In addition, FFA extraction ratios and uptake rates were determined in isolated perfused hearts using the classical Langendorff technique. After 7 days of starvation, distribution and concentrations obtained for total lipid fatty acids from heart ventricles of starved animals were substantially different from those of controls. In particular, 20:5 and 22:6 carbon polyunsaturated fatty acids were significantly elevated. Also, total plasma FFA level was elevated and FFA extraction ratios were increased as a result of prolonged starvation. Accumulation of 20- and 22-carbon polyunsaturated fatty acids observed in ventricles of starved rats may have resulted from increased availability and extraction of FFA.

KEY WORDS: • heart ventricle • plasma fatty acids • starvation.

¹ Supported in part by USPHS Training Grant No. N1GMS 1 to 2 GM 05010-01 MARC and by USPHS GRS Grant. No. 5 S07 RR 05361.

² Present address: Uniformed Service University of the Health Sciences, Physiology Department, 4301 Jones Bridge Rd., Bethesda, MD 20014.

³ To whom reprint requests should be sent.

Manuscript received 21 February 1980.

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