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An Amino Acid Diet Supporting Superior Growth in Mice¹

Department of Biochemistry, School of Medicine, University of Louisville, Louisville, Kentucky

A diet containing, as a source of nitrogen, a mixture of purified L-amino acids simulating the amino acid composition of a successful diet containing vegetable and milk proteins was fed to mice in a 3% agar gel. This diet, at 17% amino acids, supported better growth of young male animals during a 21-day period than did the same assortment of amino acids at 23% of the diet, a commercial mouse food or the same basic diet containing a different assortment of amino acids from a published diet developed for rats. Cystine was removed from the diet, which contained 0.317% methionine and no choline, and this diet, fed for 52 days, continued to support growth and produced no microscopic evidence of fatty liver.

KEY WORDS: • amino acid diet • sulfur amino acids • lipotropic factors

¹ This investigation was supported by grant #1 RO 1 CA 24108-01A1 ET, awarded by the National Cancer Institute, Department of Health, Education and Welfare.

Manuscript received 16 May 1980.