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Altered [⁶⁵Zn]Chloride Accumulation by Aged Rats' Adipocytes in Vitro¹

Department of Nutrition and Food Science, Massachusetts Institute of Technology, Cambridge, MA 02139 and USDA Human Nutrition Research Center at Tufts University, Boston, MA 02111

Accumulation of [⁶⁵Zn]chloride by isolated adipocytes from rats 11–13 months and 23–25 months old was investigated in vitro. While size and total protein per cell did not differ at the two ages, uptake of ⁶⁵Zn was depressed 40% in the adipocytes of the older animals. In contrast, serum zinc concentration was reduced marginally (15%) in the older rats. Our results suggest that altered cellular zinc metabolism may be part of the aging process.

KEY WORDS: • senescence • aging • adipocytes • zinc accumulation

¹ Supported by funds from the USDA Human Nutrition Center at Tufts University. BS was supported by a USPHS training grant.

² To whom reprint requests should be sent at: Room 56-225, M.I.T., Cambridge, MA 02139.

Manuscript received 29 August 1980.