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Journal of Nutrition Vol. 110 No. 11 November 1980, pp. 2284-2290
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Effect of Trans Fatty Acids on Serum Lecithin: Cholesterol Acyltransferase in Rats1,2,

Carolyn E. Moore2, Roslyn B. Alfin-Slater4 and Lilla Aftergood

School of Public Health, University of California, Los Angeles, CA 90024

An investigation was undertaken to study the effect of trans isomers of octadecenoic (18:1) and octadecadienoic (18:2) acids on serum lecithin:cholesterol acyltransferase (LCAT). Male rats of the Wistar strain were fed diets containing 15% fat for 9 months. The fat diets were either hydrogenated fat mixtures containing trans fatty acids, corn oil or lard. At the end of 9 months, rats were killed and serum cholesterol levels and LCAT activity were measured. It was found that free and total serum cholesterol levels were decreased when animals were fed trans fatty acids when compared with animals fed corn oil or lard. Although in vitro studies indicated that the percentage of cholesterol esterified in serum was not affected by the presence of dietary trans fatty acids, LCAT activity generally decreased when trans fatty acids were fed to rats for 9 months. In this study a negative correlation was found between serum free cholesterol and LCAT activity. Depressed total LCAT activity (µmoles of cholesterol esterified per hour per liter of serum) may have been related to a reduced amount of substrate (free cholesterol).

KEY WORDS: • LCAT • trans fatty acids • serum cholesterol

1 This work was presented in part at the meetings of the Federation of the American Societies for Experimental Biology, Dallas, TX April 1979.

2 Supported in part by a research grant from CPC International, Englewood, NJ.

3 Present address: Laboratory of Nuclear Medicine and Radiation Biology, University of California, Los Angeles, CA 90024.

4 To whom reprint requests should be sent.

Manuscript received 4 February 1980.




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