Journal of Nutrition

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Journal of Nutrition Vol. 110 No. 11 November 1980, pp. 2225-2230
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The Biological Activity of 5,6-Epoxyretinoic Acid1

M. H. Zile, R. C. Inhorn and H. F. Deluca2

Department of Biochemistry, College of Agricultural and Life Sciences, University of Wisconsin-Madison, Madison, WI 53706

The potential of all-trans-5,6-epoxyretinoic acid to promote growth in vitamin A-deficient rats was evaluated over a 25-fold dose range using single daily intraperitoneal injections. 5,6-Epoxyretinoic acid was found to be 0.5% as active as all-trans-retinoic acid. The discrepancies between the present results and those obtained previously by other workers are discussed.

KEY WORDS: • bioassay • vitamin A deficiency

1 This work was supported by a program project grant no. AM 14881 from the National Institutes of Health and by the Harry Steenbock Research Fund of the Wisconsin Alumni Research Foundation.

2 Author to whom reprint requests and all correspondence should be addressed.

Manuscript received 18 March 1980.




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