QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Purchase Article View Shopping Cart Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Radcliffe, J. D. Articles by Morrison, S. D. Search for Related Content PubMed PubMed Citation Articles by Radcliffe, J. D. Articles by Morrison, S. D.

Protein Quality, Food Intake and Growth in Normal and Walker 256 Carcinosarcoma-Bearing Rats

Laboratory of Pathophysiology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20205

The effect of supplementation of dietary gluten with its first and second limiting amino acids (lysine and threonine) on food intake and growth was examined in normal and Walker 256 carcinosarcoma-bearing male, Sprague-Dawley rats. Two diets were used. Diet G had 16.4% gluten and diet GLT had (%): gluten 15, L-lysine·HCl 1, and L-threonine, 0.4 Normal and tumor-bearing animals (7) were fed each diet from day 7 until day 20 post-transplant of the tumor bearers. Food intake in the tumor-bearers was lower than that of controls (P < 0.01) from day 10 post-transplant. Normal animals fed diet GLT ate more than those fed diet G throughout the experiment. A similar effect of protein quality on the food intake of tumor-bearers was seen until day 15 post-transplant; thereafter, food intake of tumor-bearers was similar on both diets. Tumor-bearing animals had lower (P < 0.01) protein and lipid contents than controls on both diets. Diet had no effect on tumor weight or content of protein, lipid, DNA or RNA. Protein and lipid contents of hosts and controls on diet GLT were higher (P < 0.5) than for their counterparts on diet G.

KEY WORDS: • food intake • protein quality • tumor growth • body composition

¹ To whom reprint requests should be sent at present address: Life Sciences Division, IIT Research Institute, 10 West 35th St., Chicago, IL 60616.

Manuscript received 17 March 1980.