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Enhanced Absorption of Calcium by Casein Phosphopeptides in Rachitic and Normal Chicks¹

Department of Physical Biology/Section of Physiology, New York State College of Veterinary Medicine, Cornell University, Ithaca, NY 14853

The present studies were undertaken to investigate the effect of casein phopshopeptides on calcium absorption in normal and rachitic chicks. Phosphopeptides were produced by tryptic hydrolysis of casein and the crude peptide mixture was further purified, using gel filtration. The chromatographic fractions were pooled according to their protein and phosphorus content. Some of these fractions, when introduced into the ligated duodenal loop at a concentration of 1 mg/ml or added to the mucosal solution in vitro at a concentration of 0.1 mg/ml, were capable of increasing the intestinal transport of radiocalcium. This effect was seen both in the normal and rachitic chicks, indicating that the stimulatory response was not dependent upon molecular changes induced by vitamin D. Furthermore, this response was not shared by peptides from albumin, not likely due to phosphate generated from the phosphopeptides, nor related to the phosphate content of the fractions. These experiments demonstrate that a component of milk, in addition to lactose, might account for the high availability of calcium in milk.

KEY WORDS: • calcium absorption • casein phosphopeptides • chicks

¹ Supported by grants from the National Dairy Council and the National Institute of Health (AM-04652).

² Permanent address: Department of Nutrition, University of Helsinki, 00710 Helsinki 71, Finland.

³ To whom reprint requests should be sent.

Manuscript received 17 January 1980.

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