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Biological Activity of 1,N⁶-Ethenothiamin, a Fluorescent Analog of Thiamin, in Rats¹

Graduate Section of Biochemistry, Brigham Young University, Provo, UT 84602

The ability of the recently synthesized fluorescent analog of thiamin, 1,N⁶-ethenothiamin, to substitute for thiamin in rats in vivo has been studied. 50 µg of ethenothiamin/100 g body weight/day injected in rats allowed about one-half the weight gain with 50 µg/100g/day of thiamin. The activities of the pyruvate and -keto-glutarate dehydrogenases of liver mitochondria were partially restored by 50 µg/100g/day of ethenothiamin. Ethenothiamin at this level did not appear to restore the branched-chain -keto acid dehydrogenase activities to any extent. When 150 µg of ethenothiamin/100g body weight/day was injected, growth was optimum, but these enzyme activities still did not achieve normal levels.

KEY WORDS: • ethenothiamin • thiamin

¹ Supported by a grant #AM-02448 from the National Institute of Arthritis, Metabolism and Digestive Diseases, NIH and one from Hoffmann-LaRoche, Nutley, NJ.

² To whom reprint requests should be sent.

Manuscript received 24 March 1980.