QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Purchase Article View Shopping Cart Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Wallace, W. C. Articles by Holmlund, C. E. Search for Related Content PubMed PubMed Citation Articles by Wallace, W. C. Articles by Holmlund, C. E.

Effect of Riboflavin Analogs on the Growth of Tetrahymena pyriformis

Department of Chemistry, University of Maryland, College Park, MD 20742

Several analogs of riboflavin differing with respect to the substitutent at C₇, C₈ or C₁₀ were examined for their ability to replace riboflavin and to act as riboflavin antagonists in inhibiting growth of Tetrahymena pyriformis. Generally, the analogs with altered substituents at C₇ or C₈ (the 8-ethyl, 7,8-diethyl, 7-chloro and 8-chloro analogs) supported some growth but inhibited riboflavin-supported growth. However, the 8-bromo analog had no biological activity. The 7-ethyl analog with a bis(2-hydroxyethyl)aminoethyl side chain was the most potent antagonist. These results were compared with those observed in Lactobacillus casei and the rat.

KEY WORDS: • riboflavin analogs • Tetrahymena • growth • antagonists

Manuscript received 11 March 1980.