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Effects of Aspirin and Related Drugs in Vitamin E-Deficient Rats¹

Department of Clinical Nutrition, Roche Research Center, Hoffmann-La Roche Inc., Nutley, NJ 07110 ^* Washington University, School of Medicine, St. Louis, MO 63110

Evidence from the literature indicates that in vitamin E-deficient animals prostaglandin (PG) synthesis in platelets is enhanced while it is decreased in the muscle and testis. In the present study the effects of aspirin, a known inhibitor of PG biosynthesis, on vitamin E deficiency signs in the rat were investigated. Administration of aspirin to vitamin E-deficient rats had no protective effect on fetal mortality, incisor depigmentation, body weight gain or red blood cell peroxidative hemolysis. Aspirin prevented the anemia and thrombocythemia observed in vitamin E-deficient rats. Aspirin, salicylic acid and a carbazole prostaglandin inhibitor exacerbated testis degeneration in vitamin E-deficient animals. Addition of aspirin to the diet more than doubled the vitamin E requirement for reversal of necrotizing myopathy.

KEY WORDS: • aspirin • salicylic acid • vitamin E deficiency • prostaglandin inhibitors

¹ A Preliminary report has been presented. Fed. Proc. 35, 740 (1976).

Manuscript received 16 January 1980.