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Journal of Nutrition Vol. 110 No. 10 October 1980, pp. 1940-1946
Copyright © 1980 by American Society for Nutrition
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Effect of Strain, Sex and Dietary Riboflavin on Pyridoxamine (Pyridoxine) 5'-Phosphate Oxidase Activity in Rat Tissues1

Kathleen M. Rasmussen2, Patrice M. Barsa, Donald B. McCormick3 and Daphne A. Roe

Division of Nutritional Sciences, Cornell University, Savage Hall, Ithaca, NY 14853

Weanling male rats of four strains—Buffalo, Long-Evans, Sprague-Dawley (SD) and Wistar—were fed a control or a riboflavin-deficient purified diet for 6 weeks. Both strain and diet had significant effects on pyridoxamine (pyridoxine) 5'-phosphate (PMP) oxidase activity in liver and kidney. No single strain had extreme PMP oxidase values or was consistently more responsive than the others to riboflavin deficiency. Weanling male and female SD rats were fed purified diets containing 2.5, 1.0, 0.5 or 0 mg of riboflavin/kg diet for 9 weeks. PMP oxidase values generally were lower in the females than in the males. In both sexes, increases in dietary riboflavin level were reflected in increases in PMP oxidase activity in liver and kidney. These results confirm that PMP oxidase activity is a sensitive indicator of riboflavin status in the rat.

KEY WORDS: • riboflavin • pyridoxamine-5-phosphate oxidase

1 This investigation was supported in part by USDA/SEA Agreement 5901-0410-8-0102-0 and NIH Research Grant AM-04585, USPHS.

2 Postdoctoral fellow supported by NIH Nutrition Training Grant 5-T32-AM-07158, USPHS. To whom reprint requests should be sent.

3 Present address: Department of Biochemistry, Emory University School of Medicine, Atlanta, GA 30322.

Manuscript received 25 January 1980.




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