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Journal of Nutrition Vol. 110 No. 1 January 1980, pp. 82-89
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The Effect of Long-term Feeding of 10% Dietary Lactose on Serum, Liver and Aortic Cholesterol of the Rat and the Gerbil1

Bernard S. Wostmann and Edith Bruckner-Kardoss

Lobund Laboratory, Department of Microbiology, University of Notre Dame, Notre Dame, IN 46556

Rats and gerbils were maintained on a casein-starch diet containing 0.1% cholesterol and 10% lactose. Serum cholesterol was determined at 4, 6, 9, 12, 15, 18, 21 and 24 months of age. At 12 and 24 months, liver and aortic cholesterol were determined. Addition of lactose had no effect in rats, except for a slight cecal enlargement and a minor shift in secondary bile acids. Both lactose-fed and control animals showed steadily increasing serum cholesterol concentrations until 21 months when a plateau of 170 mg/dl was reached. Aortic cholesterol increased by 38% between 12 and 24 months, based on dry tissue. Gerbils showed a maximum serum cholesterol concentration at 12 months of age. Liver cholesterol content also decreased during the second half of life. Serum cholesterol values were higher at all times in the lactose-fed gerbils, but the difference was significant only from 9 to 18 months. While serum and liver cholesterol values decreased during the second year of life, aortic cholesterol of the gerbil remained at the same level. The data indicate that in the gerbil, with its cholesterol metabolism more comparable to man than that of the rat, lactose intake in the range of possible human consumption does affect cholesterol metabolism.

KEY WORDS: • cholesterol • lactose • rats • gerbils

1 Supported in part by a grant from the Fannie E. Rippel Foundation, Morristown, NJ.

Manuscript received 11 May 1979.




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