Journal of Nutrition

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Journal of Nutrition Vol. 110 No. 1 January 1980, pp. 74-81
Copyright © 1980 by American Society for Nutrition
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The Effects of Vitamin E Depletion and Repletion on Prostaglandin Dehydrogenase Activity in Tissues of Young Rabbits1

Alvin C. Chan2, P. Vincent J. Hegarty and C. Eugene Allen

Department of Food Science and Nutrition and Department of Animal Science, University of Minnesota, St. Paul, MN 55108

The key enzyme controlling prostaglandin (PG) catabolism, 15-hydroxyprostaglandin dehydrogenase (PGDH), was characterized in rabbit tissues. The apparent Michaelis constant (Km) using PGE2 as substrate was found to be 5.3, 4.0, 4.0 and 7.1 µM for semitendinosus and soleus muscles, heart and kidney, respectively. The effect of dietary vitamin E depletion and repletion on the PGDH activity in these tissues was studied. Vitamin E deficiency caused an elevation of PGDH activity in rabbit skeletal muscles but not in the heart and kidney. Oral supplementation of tocopherol acetate to the deficient animals did not affect the skeletal muscle PGDH activity. A long period of refeeding (30 days) was required to suppress the elevated PGDH level to the control values. The data indicates a higher turnover of the PGs in the vitamin E-deficient rabbit skeletal muscles. The significance of such a change in connection to prostaglandin metabolism is discussed.

KEY WORDS: • vitamin E • prostaglandin • dehydrogenase activity • rabbits • 15-hydroxyprostaglandin dehydrogenase

1 Scientific Journal Series, Paper No. 10,762, Minnesota Agricultural Experiment Station.

2 Present address: Dept. of Foods and Nutrition, University of Manitoba, Winnipeg, Manitoba, Canada, R3T 2N2, where reprint requests should be sent.

Manuscript received 20 April 1979.




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